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Doe Boy Fresh is a song by rap group Three 6 Mafia, originally the first single from their ninth studio album, Last 2 Walk, but was ultimately cut from the album. The final track listing does not include the song, possibly due to the numerous album delays. The song features Chamillionaire. The song was released on January 2, 2007 as a digital download single on iTunes but was leaked in December 2006. For unknown reasons, the single was removed from the iTunes store in early 2009. However, the other singles cut from the album, "Like Money" and "Sugar Daddy" remain in the store.

The title "Doe Boy Fresh" is the censored title, used on the radio, TV and CD covers. The uncensored title, "Dope Boy Fresh", cannot be used as it violated censorship rules. In slang, "dope boy fresh" describes a prosperous drug-dealer.

The music video premiered on MTV.com on February 9, 2007. Travis Barker makes an appearance in the video, which contains various people briefly being either Three 6 Mafia or Chamillionaire. Actor Tom Bower, from Die Hard 2 and The Hills Have Eyes, makes an appearance as the first portal viewer. The style of the video is inspired by the 1999 film Being John Malkovich where, due to a strange portal, entered the life of the titled actor. The single reached #54 on the Billboard Hot 100.